Optimising low-dose methotrexate for rheumatoid arthritis—a review

Title: Optimising low-dose methotrexate for rheumatoid arthritis—a review
Creator: Lucas, Catherine J.; Dimmitt, Simon B.; Martin, Jennifer H.
Relation: British Journal of Clinical Pharmacology Vol. 85, Issue 10, p. 2228-2234
Publisher Link: http://dx.doi.org/10.1111/bcp.14057
Publisher: Wiley-Blackwell
Resource Type: journal article
Date: 2019
Description: Methotrexate at low doses (5-25 mg/week) is first-line therapy for rheumatoid arthritis. However, there is inter- and intrapatient variability in response, with contribution of variability in concentrations of active polyglutamate metabolites, associated with clinical efficacy and toxicity. Prescribing remains heterogeneous across population groups, disease states and regimens. This review examines current knowledge of dose-response of oral methotrexate in the setting of rheumatoid arthritis, and how this could help inform dosage regimens.
Subject: clinical pharmacolaogy; methotrexate; pharmacodynamics; pharmacokinetics; prescribing; rheumatoid arthritis
Identifier: http://hdl.handle.net/1959.13/1442554
Identifier: uon:41720
Identifier: ISSN:0306-5251
Language: eng
Reviewed

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